Findings

What do systematic reviews say?

5 questions · 5 findings · 3 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 80%Low 1 · 20%Moderate 0 · 0%High 0 · 0%

Hydroxyurea vs placebo

All‐cause mortality · people with sickle cell disease

1 finding from 1 review · compare the 2 reviews

Interventions for chronic kidney disease in people with sickle cell disease 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 193 participants
Low

Hydroxyurea vs RBC transfusion

All‐cause mortality · prevention of SCI in people with SCD who have not had a stroke (primary prevention)

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1 participants
Very low

Hydroxyurea vs RBC transfusion

All‐cause mortality · prevention of SCI in people with SCD who had a stroke (secondary prevention)

It is very uncertain whether hydroxyurea changes all‐cause mortality compared with RBC transfusion (very low certainty).

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
OR 1.02 [0.06, 16.41]
1 study · 133 participants
Very low

Long‐term red cell transfusion vs hydroxyurea and phlebotomy

All‐cause mortality · individuals with sickle cell disease who are at risk of a primary stroke who have had long‐term red cell transfusions to prevent a stroke

1 finding from 1 review

Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 121 participants
Very low

Long‐term red cell transfusion vs hydroxyurea and phlebotomy

All‐cause mortality · individuals with sickle cell disease who have had a stroke who have had long‐term red cell transfusions to prevent another stroke

It is very uncertain whether long‐term red cell transfusion changes all‐cause mortality compared with hydroxyurea and phlebotomy (very low certainty).

1 finding from 1 review

Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease 2020 · Cochrane Headline outcomes only
Peto OR 0.98 [0.06, 15.92]
1 study · 133 participants
Very low