Findings

What do systematic reviews say?

12 questions · 12 findings · 4 reviews

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No studies found 0 · 0%GRADE not reported 3 · 25%Very low 1 · 8.3%Low 5 · 41.7%Moderate 3 · 25%High 0 · 0%

Adults: formoterol/ICS vs salmeterol/ICS

All‐cause mortality formoterol/budesonide vs salmeterol/budesonide · adults, chronic asthma: all‐cause mortality

1 finding from 1 review

Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and an… 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 229 participants
GRADE not reported

Adults: formoterol/ICS vs salmeterol/ICS

All‐cause mortality ‐ formoterol and budesonide vs salmeterol and fluticasone · adults, chronic asthma: all‐cause mortality

Adults: formoterol/ICS showed no clear difference in all‐cause mortality ‐ formoterol/budesonide vs salmeterol/fluticasone compared with salmeterol/ICS (low certainty).

1 finding from 1 review

Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and an… 2021 · Cochrane Headline outcomes only
OR 1.03 [0.06, 16.44]
7 studies · 5935 participants
Low

Adults: formoterol/ICS vs salmeterol/ICS

All‐cause mortality ‐ formoterol/mometasone vs salmeterol/fluticasone · adults, chronic asthma: all‐cause mortality

Adults: formoterol/ICS showed no clear difference in all‐cause mortality ‐ formoterol/mometasone vs salmeterol/fluticasone compared with salmeterol/ICS (low certainty).

1 finding from 1 review

Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and an… 2021 · Cochrane Headline outcomes only
OR 4.46 [0.23, 85.4]
2 studies · 1126 participants
Low

Adults: formoterol/ICS vs salmeterol/ICS

All‐cause mortality ‐ formoterol/fluticasone vs salmeterol/fluticasone · adults, chronic asthma: all‐cause mortality

Adults: formoterol/ICS showed no clear difference in all‐cause mortality ‐ formoterol/fluticasone vs salmeterol/fluticasone compared with salmeterol/ICS (low certainty).

1 finding from 1 review

Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and an… 2021 · Cochrane Headline outcomes only
OR 7.39 [0.15, 372.38]
2 studies · 270 participants
Low

Adults: formoterol/ICS vs salmeterol/ICS

Mortality (all‐cause) ‐ formoterol versus salbutamol ( · adults, chronic asthma: all‐cause mortality

1 finding from 1 review

Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and an… 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 1257 participants
GRADE not reported

Regular formoterol and ICS vs same‐dose ICS

All‐cause mortality · adults, chronic asthma: all‐cause mortality

Regular formoterol and ICS showed no clear difference in all‐cause mortality compared with same‐dose ICS (moderate certainty).

1 finding from 1 review

Inhaled steroids with and without regular formoterol for asthma: serious adverse events 2019 · Cochrane Headline outcomes only
OR 1.25 [0.61, 2.56]
32 studies · 35751 participants
Moderate

Regular formoterol and ICS vs same‐dose ICS

All‐cause mortality · children and adolescents with chronic asthma

1 finding from 1 review

Inhaled steroids with and without regular formoterol for asthma: serious adverse events 2019 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 4035 participants
Low

Regular formoterol vs regular salmeterol

All‐cause mortality in adults · people with asthma

1 finding from 1 review

Regular treatment with formoterol versus regular treatment with salmeterol for chronic asthma: serious adverse events 2012 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1116 participants
Low

Regular formoterol vs regular salmeterol

All‐cause mortality in children · people with asthma

1 finding from 1 review

Regular treatment with formoterol versus regular treatment with salmeterol for chronic asthma: serious adverse events 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 156 participants
Very low

Children: formoterol/fluticasone vs regular salmeterol and fluticasone

All‐cause mortality · children with chronic asthma

1 finding from 1 review

Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and an… 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 548 participants
GRADE not reported

Intervention not reported

Mortality (all‐cause) ‐ formoterol versus placebo ( · patients with chronic asthma

The intervention showed no clear difference in mortality (all‐cause) ‐ formoterol versus placebo ( (moderate certainty).

1 finding from 1 review

Regular treatment with formoterol for chronic asthma: serious adverse events 2012 · Cochrane Headline outcomes only
OR 1.52 [0.24, 9.71]
14 studies · 5463 participants
Moderate

Intervention not reported

Mortality (all‐cause) ‐ formoterol versus salbutamol ( · patients with chronic asthma

The intervention showed no clear difference in mortality (all‐cause) ‐ formoterol versus salbutamol ( (moderate certainty).

1 finding from 1 review

Regular treatment with formoterol for chronic asthma: serious adverse events 2012 · Cochrane Headline outcomes only
OR 0.5 [0.03, 8.05]
6 studies · 1418 participants
Moderate