Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 1 · 33.3%Very low 1 · 33.3%Low 1 · 33.3%Moderate 0 · 0%High 0 · 0%

Long‐term red cell transfusion vs no transfusion

Adverse events associated with transfusion · individuals with sickle cell disease who are at risk of a primary stroke who have had long‐term red cell transfusions to prevent a stroke

1 finding from 1 review

Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 79 participants
GRADE not reported

Long‐term red cell transfusion vs no transfusion

Adverse events associated with transfusion · individuals with sickle cell disease who are at risk of a primary stroke who have not had previous long‐term red cell transfusions

It is very uncertain whether long‐term red cell transfusion changes adverse events associated with transfusion compared with no transfusion (very low certainty).

1 finding from 1 review

Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 3.16 [0.18, 57.17]
1 study · 121 participants
Very low

Long‐term red cell transfusion vs hydroxyurea and phlebotomy

Adverse events associated with transfusion · individuals with sickle cell disease who are at risk of a primary stroke who have had long‐term red cell transfusions to prevent a stroke

1 finding from 1 review

Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 121 participants
Low