Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews · Gynaecology and Fertility

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 25%Low 3 · 75%Moderate 0 · 0%High 0 · 0%

Metformin vs metformin combined with OCP

Adverse events ‐ Severe · adult women with PCOS

Metformin showed no clear difference in adverse events ‐ Severe compared with metformin combined with oral contraceptive pill (OCP) (low certainty).

1 finding from 1 review

Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
OR 0.74 [0.21, 2.53]
3 studies · 171 participants
Low

Metformin vs oral contraceptive pill (OCP)

Adverse events ‐ Severe · adult women with PCOS

Metformin may leads to higher adverse events ‐ Severe compared with oral contraceptive pill (OCP) (low certainty).

1 finding from 1 review

Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
OR 6.42 [2.98, 13.84]
11 studies · 602 participants
Low

Oral contraceptive pill (OCP) vs metformin combined with OCP

Adverse events ‐ Severe · aAdult women with PCOS

Oral contraceptive pill (OCP) may leads to lower adverse events ‐ Severe compared with metformin combined with OCP (low certainty).

1 finding from 1 review

Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
OR 0.2 [0.06, 0.72]
5 studies · 228 participants
Low

Oral contraceptive pill (OCP) vs metformin combined with OCP

Adverse events ‐ Severe · adolescent women with PCOS

It is very uncertain whether oral contraceptive pill (OCP) changes adverse events ‐ Severe compared with metformin combined with OCP (very low certainty).

1 finding from 1 review

Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
OR 1 [0.06, 17.33]
1 study · 36 participants
Very low