Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

6 questions · 6 findings · 1 reviews · Common Mental Disorders

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 50%Low 1 · 16.7%Moderate 0 · 0%High 2 · 33.3%

Valproate vs RISPERIDONE

Adverse effects: 1. Sedation · Children and adolescents with acute mania

It is very uncertain whether valproate changes adverse events ‐ Sedation At 8 weeks (secondary tolerability outcome) compared with risperidone (very low certainty).

1 finding from 1 review

Valproate vs OLANZAPINE

Adverse effects: 1. Sedation · Adults (aged 18 and over) with acute mania

Valproate leads to lower adverse events ‐ Sedation At 3‐12 weeks (secondary tolerability… compared with olanzapine (high certainty).

1 finding from 1 review

Valproate vs lithium

Adverse effects: 1. Sedation · Adults (aged 18 and over) with acute mania

Valproate showed no clear difference in individual adverse events ‐ Sedation At 3 weeks (secondary… compared with lithium (low certainty).

1 finding from 1 review

Valproate vs lithium

Adverse events: somnolence/sedation · Children and adolescents with acute mania

It is very uncertain whether valproate changes individual adverse events ‐ Sedation At 8 weeks (secondary… compared with lithium (very low certainty).

1 finding from 1 review

Valproate vs placebo

Adverse effects: 1. Sedation · Children and adolescents with acute mania

It is very uncertain whether valproate changes individual adverse events ‐ Sedation At 4 weeks (secondary… compared with placebo (very low certainty).

1 finding from 1 review

Valproate vs placebo

Adverse effects: 1. Sedation · Adults (aged 18 and over) with acute mania

Valproate showed no clear difference in individual adverse events ‐ Sedation At 3‐8 weeks (secondary… compared with placebo (high certainty).

1 finding from 1 review