Evidence Gaps

What do systematic reviews say?

1 questions · 2 findings · 2 reviews · Gynaecology and Fertility

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Metformin combined with clomiphene citrate vs clomiphene

Gastrointestinal adverse events · women with polycystic ovary syndrome

Metformin combined with clomiphene citrate probably leads to higher adverse events (gastrointestinal) per woman compared with clomiphene citrate alone (moderate certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 4.26 [2.83, 6.4]
6 studies · 852 participants
Moderate
Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 3.97 [2.59, 6.08]
3 studies · 591 participants
Moderate