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What do systematic reviews say?

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Evidence found and GRADE certainty

4 questions · 6 findings · 2 reviews · Gynaecology and Fertility

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No studies found 2 · 33.3%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 4 · 66.7%High 0 · 0%

Metformin vs clomiphene

Gastrointestinal adverse events · women with polycystic ovary syndrome

The review found no eligible studies for this question.

2 findings from 2 reviews · compare the 2 reviews

Metformin vs placebo or no treatment

Gastrointestinal adverse events · Women with polycystic ovary syndrome, oligo amenorrhoea and subfertility

Metformin probably leads to higher adverse events (gastrointestinal) per woman compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Metformin combined with clomiphene citrate vs clomiphene

Gastrointestinal adverse events · women with polycystic ovary syndrome

Metformin combined with clomiphene citrate probably leads to higher adverse events (gastrointestinal) per woman compared with clomiphene citrate alone (moderate certainty).

2 findings from 2 reviews · compare the 2 reviews