Findings

What do systematic reviews say?

2 questions · 2 findings · 2 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 50%Low 0 · 0%Moderate 1 · 50%High 0 · 0%

Statins with cholesterol supplementation vs cholesterol supplementation only

Statin‐related adverse events · children and adults with Smith‐Lemli‐Opitz syndrome

It is very uncertain whether statins with cholesterol supplementation changes statin‐related adverse events compared with cholesterol supplementation only (very low certainty).

1 finding from 1 review

Statins for Smith‐Lemli‐Opitz syndrome 2022 · Cochrane Headline outcomes only
RR 0.33 [0.01, 7.68]
1 study · 18 participants
Very low

Intervention not reported

Adverse events ‐ at one year · children with familial hypercholesterolemia

The intervention showed no clear difference in adverse events ‐ at one year (moderate certainty).

1 finding from 1 review

Statins for children with familial hypercholesterolemia 2019 · Cochrane Headline outcomes only
RR 1.01 [0.81, 1.26]
2 studies · 276 participants
Moderate