Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

24 questions · 27 findings · 6 reviews · Haematology

No studies found 9 · 33.3%GRADE not reported 1 · 3.7%Very low 5 · 18.5%Low 11 · 40.7%Moderate 0 · 0%High 1 · 3.7%

Intervention not reported

Adverse events requiring discontinuation of CSFs · Prevention and treatment of infectious complications in patients with acute myelogenous leukemia

It is very uncertain whether the intervention changes adverse events requiring discontinuation of CSFs (very low certainty).

1 finding from 1 review

Casirivimab/imdevimab vs placebo

Adverse events: grade 1 to 2 · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

The review found no eligible studies for this question.

2 findings from 1 review

Casirivimab/imdevimab vs placebo

Serious adverse events within 6 months · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

It is very uncertain whether casirivimab/imdevimab changes serious adverse events within 6 months compared with placebo (very low certainty).

1 finding from 1 review

Casirivimab/imdevimab vs placebo

Adverse events: all grades · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Casirivimab/imdevimab showed no clear difference in adverse events: all grades within 6 months compared with placebo (low certainty).

2 findings from 1 review

Casirivimab/imdevimab vs placebo

Serious adverse events until data cut‐offb · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Casirivimab/imdevimab showed no clear difference in serious adverse events until data cut‐offb compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

Any adverse events during the trial period · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

The intervention showed no clear difference in any adverse events during the trial period (low certainty).

1 finding from 1 review

Intervention not reported

Any adverse events during the trial period · people with moderate to severe disease (WHO scale 4–9); all trials contributing results to the summary of findings table investigated…

The intervention showed no clear difference in any adverse events during the trial period (low certainty).

1 finding from 1 review

Casirivimab/imdevimab vs placebo

Grades 3 and 4 adverse events · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

It is very uncertain whether casirivimab/imdevimab changes adverse events: grade 3 to 4 within 6 months compared with placebo (very low certainty).

2 findings from 1 review