Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews · Gut

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 66.7%Low 1 · 33.3%Moderate 0 · 0%High 0 · 0%

Usual care vs immunosuppressive withdrawal after monotherapy

Adverse events · Participants with Crohn's disease in remission

Usual care showed no clear difference in adverse events compared with immunosuppressive withdrawal after monotherapy (low certainty).

1 finding from 1 review

Withdrawal of immunosuppressant or biologic therapy for patients with quiescent Crohn's disease 2018 · Cochrane Headline outcomes only
RR 0.88 [0.67, 1.17]
3 studies · 186 participants
Low

Usual care vs immunosuppressive withdrawal after monotherapy

Serious adverse events · Participants with Crohn's disease in remission

It is very uncertain whether usual care changes serious adverse events compared with immunosuppressive withdrawal after monotherapy (very low certainty).

1 finding from 1 review

Withdrawal of immunosuppressant or biologic therapy for patients with quiescent Crohn's disease 2018 · Cochrane Headline outcomes only
RR 3.29 [0.35, 30.8]
2 studies · 134 participants
Very low

Usual care vs immunosuppressive withdrawal after monotherapy

Withdrawals due to adverse events · Participants with Crohn's disease in remission

It is very uncertain whether usual care changes withdrawal due to adverse events compared with immunosuppressive withdrawal after monotherapy (very low certainty).

1 finding from 1 review

Withdrawal of immunosuppressant or biologic therapy for patients with quiescent Crohn's disease 2018 · Cochrane Headline outcomes only
RR 2.59 [0.35, 19.04]
2 studies · 135 participants
Very low