Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews · Gynaecology and Fertility

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 33.3%Moderate 2 · 66.7%High 0 · 0%

Adverse events · women with uterine fibroids

GnRHa treatment probably leads to higher adverse events compared with placebo or no pretreatment (preoperative outcomes) (moderate certainty).

1 finding from 1 review

Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
OR 2.78 [1.77, 4.36]
4 studies · 755 participants
Moderate

Adverse events (hot flushes) · women with uterine fibroids

GnRHa treatment may leads to higher adverse events (hot flushes) compared with other medical therapies before any surgery (low certainty).

1 finding from 1 review

Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
OR 12.3 [4.04, 37.48]
5 studies · 453 participants
Low

Adverse events · heavy menstrual bleeding

LNG‐IUS probably leads to lower adverse events compared with any other medical treatment (moderate certainty).

1 finding from 1 review

Progestogen‐releasing intrauterine systems for heavy menstrual bleeding 2020 · Cochrane Headline outcomes only
RR 0.91
1 study · 571 participants
Moderate