Findings

What do systematic reviews say?

9 questions · 9 findings · 4 reviews · Gynaecology and Fertility

No studies found 1 · 11.1%GRADE not reported 0 · 0%Very low 2 · 22.2%Low 2 · 22.2%Moderate 4 · 44.4%High 0 · 0%

Adverse events · heavy menstrual bleeding

LNG‐IUS probably leads to lower adverse events compared with any other medical treatment (moderate certainty).

1 finding from 1 review

Progestogen‐releasing intrauterine systems for heavy menstrual bleeding 2020 · Cochrane Headline outcomes only
RR 0.91
1 study · 571 participants
Moderate

Adverse events (hot flushes) · women with uterine fibroids

GnRHa treatment may leads to higher adverse events (hot flushes) compared with other medical therapies before any surgery (low certainty).

1 finding from 1 review

Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
OR 12.3 [4.04, 37.48]
5 studies · 453 participants
Low

Adverse events · women with uterine fibroids

The review found no eligible studies for this question.

1 finding from 1 review

Adverse events · women with uterine fibroids

SPRM showed no clear difference in adverse events compared with placebo (low certainty).

1 finding from 1 review

Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
OR 0.05 [0, 1]
1 study · 241 participants
Low

Adverse events · women with uterine fibroids

GnRHa treatment probably leads to higher adverse events compared with placebo or no pretreatment (preoperative outcomes) (moderate certainty).

1 finding from 1 review

Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
OR 2.78 [1.77, 4.36]
4 studies · 755 participants
Moderate

Adverse events at 4 months · women with heavy menstrual bleeding

Surgery probably leads to lower adverse events at 4 months compared with oral medication (moderate certainty).

1 finding from 1 review

Surgery versus medical therapy for heavy menstrual bleeding 2016 · Cochrane Headline outcomes only
RR 0.26 [0.15, 0.46]
1 study · 186 participants
Moderate

Adverse events (spotting at 3 and 6 months) · women with uterine fibroids

1 finding from 1 review

Adverse events (hot flushes) · women with uterine fibroids

1 finding from 1 review

Proportion of women with adverse events Endometrial ablation versus LNG‐IUS. At one year · women with heavy menstrual bleeding

Surgery probably leads to lower proportion of women with adverse events Endometrial ablation versus… compared with LNG‐IUS (moderate certainty).

1 finding from 1 review

Surgery versus medical therapy for heavy menstrual bleeding 2016 · Cochrane Headline outcomes only
RR 0.51 [0.36, 0.74]
3 studies · 201 participants
Moderate