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Evidence found and GRADE certainty

15 questions · 15 findings · 3 reviews · Headline outcomes only

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No studies found 9 · 60%GRADE not reported 0 · 0%Very low 1 · 6.7%Low 2 · 13.3%Moderate 3 · 20%High 0 · 0%

Lithium vs QUETIAPINE

Adverse events · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs OLANZAPINE

Adverse events · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs chlorpromazine

Adverse events · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs haloperidol

Adverse events · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs clonazepam

Adverse events · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs ECT

Adverse events · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs ARIPIPRAZOLE

Adverse event: tremor · acute mania

Lithium showed no clear difference in adverse events: tremor compared with aripiprazole (moderate certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 1.45 [0.65, 3.24]
    1 study · 313 participants
    Moderate

Lithium vs ARIPIPRAZOLE

Adverse events: somnolence/sedation · acute mania

Lithium showed no clear difference in adverse events: somnolence/sedation compared with aripiprazole (moderate certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 0.56 [0.26, 1.23]
    1 study · 313 participants
    Moderate

Lithium vs RISPERIDONE

Drowsiness/somnolence (Event rate during treatment, length of treatment varied across trials) · acute mania

Lithium probably leads to lower adverse events: drowsiness/ somnolence compared with risperidone (moderate certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 0.43 [0.24, 0.75]
    2 studies · 219 participants
    Moderate

Lithium vs ARIPIPRAZOLE

Adverse events: clinically relevant (> 7%) weight gain · acute mania

Lithium showed no clear difference in adverse events: clinically relevant (> 7%) weight gain compared with aripiprazole (low certainty).

1 finding from 1 review

Valproate vs lithium

Adverse effects: 1. Sedation · Adults (aged 18 and over) with acute mania

Valproate showed no clear difference in individual adverse events ‐ Sedation At 3 weeks (secondary… compared with lithium (low certainty).

1 finding from 1 review

Valproate vs lithium

Adverse events: somnolence/sedation · Children and adolescents with acute mania

It is very uncertain whether valproate changes individual adverse events ‐ Sedation At 8 weeks (secondary… compared with lithium (very low certainty).

1 finding from 1 review