Findings

What do systematic reviews say?

2 questions · 2 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 50%Low 0 · 0%Moderate 1 · 50%High 0 · 0%

Human activated protein C vs heparin

Adverse events · DIC

It is very uncertain whether human activated protein C changes adverse events compared with heparin (very low certainty).

1 finding from 1 review

Treatment for disseminated intravascular coagulation in patients with acute and chronic leukemia 2015 · Cochrane Headline outcomes only
RR 0.53 [0.05, 5.66]
1 study · 107 participants
Very low

Human recombinant activated protein C vs placebo

Serious adverse events (adult and paediatric patients) · patients with severe sepsis or septic shock

Human recombinant activated protein C showed no clear difference in serious adverse events (adult and paediatric patients) compared with placebo (moderate certainty).

1 finding from 1 review

Human recombinant protein C for severe sepsis and septic shock in adult and paediatric patients 2012 · Cochrane Headline outcomes only
RR 1.04 [0.92, 1.18]
5 studies · 6636 participants
Moderate