What do systematic reviews say?

Comparison 2: any simplified antibiotic regimen vs 7 days injectable benzylpenicillin + injectable gentamicin

Comparison 2: any simplified antibiotic regimen showed no clear difference in adverse events compared with the standard antibiotic regimen (7 days injectable benzylpenicillin… (moderate certainty).

• Community‐based antibiotic delivery for possible serious bacterial infections in neonates in low‐ and middle‐income… 2019 · Cochrane Headline outcomes only
  RR 1.38 [0.79, 2.41]
  3 studies · 3476 participants
  Moderate

Comparison 2: 7 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

• Community‐based antibiotic delivery for possible serious bacterial infections in neonates in low‐ and middle‐income… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 1406 participants
  Moderate

Comparison 2: 7 days oral amoxicillin + injectable gentamicin vs 7 days injectable benzylpenicillin + injectable gentamicin

Comparison 2: 7 days oral amoxicillin + injectable gentamicin showed no clear difference in adverse events compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

• Community‐based antibiotic delivery for possible serious bacterial infections in neonates in low‐ and middle‐income… 2019 · Cochrane Headline outcomes only
  RR 1.35 [0.72, 2.53]
  3 studies · 2001 participants
  Moderate

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

• Community‐based antibiotic delivery for possible serious bacterial infections in neonates in low‐ and middle‐income… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 893 participants
  High

Comparison 2: 2 days injectable benzylpenicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Comparison 2: 2 days injectable benzylpenicillin + injectable… showed no clear difference in adverse events compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

• Community‐based antibiotic delivery for possible serious bacterial infections in neonates in low‐ and middle‐income… 2019 · Cochrane Headline outcomes only
  RR 1.39 [0.67, 2.87]
  3 studies · 2036 participants
  Moderate