Findings

What do systematic reviews say?

2 questions · 3 findings · 1 reviews · Schizophrenia

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 33.3%Moderate 2 · 66.7%High 0 · 0%

Adverse effects: 1. General ‐ overall number of events · people with psychosis

Any antiglucocorticoid probably leads to higher adverse effects: 1. General ‐ overall number of events compared with placebo (moderate certainty).

2 findings from 1 review

Antiglucocorticoid and related treatments for psychosis 2016 · Cochrane Headline outcomes only
RR 2.66 [1.33, 5.32]
7 studies · 199 participants
Moderate
Antiglucocorticoid and related treatments for psychosis 2016 · Cochrane Headline outcomes only
RR 0.92 [0.77, 1.09]
2 studies · 226 participants
Moderate

Adverse events: 2. Specific ‐ extrapyramidal symptoms ‐ average endpoint scores ‐ data only for DHEA SHRS total · people with psychosis

1 finding from 1 review

Antiglucocorticoid and related treatments for psychosis 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Low