Findings

What do systematic reviews say?

6 questions · 6 findings · 5 reviews · Oral Health

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No studies found 2 · 33.3%GRADE not reported 3 · 50%Very low 1 · 16.7%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic

Adverse events · Adults undergoing dental implant placement

Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in adverse events compared with no antibiotics or placebo; GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications 2013 · Cochrane All outcomes
3 to 5 months
RR 1.0 [0.06, 15.85]
6 studies · 1162 participants
GRADE not reported

Antibiotic prophylaxis before dental procedure vs placebo or no prophylaxis

Mortality or serious adverse events requiring hospital admission · Adults or children at increased risk of bacterial endocarditis (pre-existing cardiac condition) undergoing an invasive dental procedure

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotic prophylaxis for preventing bacterial endocarditis following dental procedures 2022 · Cochrane All outcomes
Mortality or serious adverse events requiring hospitalisation | No data reported | 248 (1 study) | - | -
0 studies
No studies found

Systemic antibiotic (oral penicillin 500 mg) plus analgesic vs Placebo plus analgesic

Number of adverse events · Adults over 18 years presenting with a single tooth with a clinical diagnosis of irreversible pulpitis

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotic use for irreversible pulpitis 2019 · Cochrane All outcomes
Number of adverse events: Outcome not reported.
Studies not reported
No studies found

Amoxicillin + metronidazole + SRP vs Supragingival scaling (plus placebo)

Adverse events due to periodontal therapy · People with periodontitis and metabolic syndrome (no CVD; primary prevention)

It is very uncertain whether scaling and root planing (SRP) plus antibiotics (amoxicillin and… changes adverse events due to periodontal therapy compared with supragingival scaling (plus placebo) (very low certainty).

1 finding from 1 review

Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis 2022 · Cochrane All outcomes
12 months
Peto OR 0.14 [0.00, 6.90]
1 study · 165 participants
Very low

Full-mouth disinfection (FMD): scaling/root planing (subgingival instrumentation) of all quadrants within 24 hours plus adjunctive antiseptic (chlorhexidine) treatments (rinsing, pocket irrigation, tongue/tonsil brushing) vs Quadrant scaling and root planing (control): SRP of each quadrant in separate sessions at least one week apart

Adverse events · Adults with a clinical diagnosis of (chronic) periodontitis (1999 classification); studies of aggressive periodontitis, systemic disorders…

1 finding from 1 review

Full‐mouth treatment modalities (within 24 hours) for periodontitis in adults 2022 · Cochrane All outcomes
13 studies provided adverse-event/participant-reported information; 3 reported an event after FMD or FMS; most important harm was increased body temperature. FMD/chlorhexidine-specific harms reported by Fonseca 2015…
13 studies
GRADE not reported

Full-mouth scaling (FMS): scaling/root planing (subgingival instrumentation) of all quadrants within 24 hours, without antiseptic vs Quadrant scaling and root planing (control): SRP of each quadrant in separate sessions at least one week apart

Adverse events · Adults with a clinical diagnosis of (chronic) periodontitis (1999 classification); studies of aggressive periodontitis, systemic disorders…

1 finding from 1 review

Full‐mouth treatment modalities (within 24 hours) for periodontitis in adults 2022 · Cochrane All outcomes
13 studies provided adverse-event/participant-reported information; 3 reported an event after FMD or FMS; most important harm was increased body temperature after treatment. Narrative, not separated by comparison and…
13 studies
GRADE not reported