Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,199 questions · 1,226 findings · 451 reviews

No studies found 289 · 23.6%GRADE not reported 121 · 9.9%Very low 350 · 28.5%Low 279 · 22.8%Moderate 139 · 11.3%High 48 · 3.9%

Long‐term red cell transfusion vs hydroxyurea and phlebotomy

Serious adverse events as a result of sickle cell‐related complications · individuals with sickle cell disease who have had a stroke who have had long‐term red cell transfusions to prevent another stroke

It is very uncertain whether long‐term red cell transfusion changes serious adverse events as a result of sickle cell‐related… compared with hydroxyurea and phlebotomy (very low certainty).

1 finding from 1 review

Long‐term red cell transfusion vs no transfusion

Serious adverse events as a result of sickle cell‐related complications · individuals with sickle cell disease who are at risk of a primary stroke who have not had previous long‐term red cell transfusions

Long‐term red cell transfusion may leads to lower serious adverse events as a result of sickle cell‐related… compared with no transfusion (low certainty).

1 finding from 1 review

Intervention not reported

Adverse events ‐ Withdrawn for medical reasons: Tricyclics versus placebo · patients with depression during opioid agonist treatment for opioid dependence

The intervention leads to higher adverse events ‐ Withdrawn for medical reasons: Tricyclics versus… (high certainty).

1 finding from 1 review

Bae: AZT/3TC/NVP vs Other Short Course Regimen

Maternal Grade 3/4 Severe Adverse Events Requiring Treatment Modification · HIV‐infected pregnant women

It is very uncertain whether tonwe‐Gold: AZT/3TC/NVP changes maternal Grade 3/4 Severe Adverse Events Requiring Treatment… compared with other Short Course Regimen (very low certainty).

1 finding from 1 review

Dose comparison: oestrogen 100 µg patch vs 200 µg patch plus progestogen

Adverse events ‐ specific side effects attributed to oestrogen over 8 months' · women with PMS

It is very uncertain whether dose comparison: oestrogen 100 µg patch changes adverse events ‐ specific side effects attributed to oestrogen over… compared with 200 µg patch plus progestogen (very low certainty).

1 finding from 1 review

Intervention not reported

Non‐serious local adverse events (low risk of bias) inactivated HAV vaccine ICH‐GCP 1997 · patients with preventing hepatitis A.

The intervention showed no clear difference in non‐serious local adverse events (low risk of bias) inactivated HAV… (high certainty).

1 finding from 1 review

Intervention not reported

Non‐serious systemic adverse events (low risk of bias) inactivated HAV vaccine ICH‐GCP 1997 · patients with preventing hepatitis A.

The intervention showed no clear difference in non‐serious systemic adverse events (low risk of bias) inactivated… (high certainty).

1 finding from 1 review

Intervention not reported

Non‐serious local adverse events (low risk of bias) live attenuated HAV vaccine ICH‐GCP 1997 · patients with preventing hepatitis A.

The review found no eligible studies for this question.

1 finding from 1 review

Psychological therapy vs usual care or attention control

Adverse events: all ‐ other events ‐ not listed above (e.g. dysuria, neck pain, eye discomfort) (secondary outcome) · people with depression after stroke

It is very uncertain whether psychological therapy changes adverse events: all ‐ other events ‐ not listed above (e.g. fall,… compared with usual care and/or attention control (very low certainty).

1 finding from 1 review

Intervention not reported

Non‐serious systemic adverse events (all included studies) inactivated HAV vaccine ICH‐GCP 1997 · patients with preventing hepatitis A.

The intervention showed no clear difference in non‐serious systemic adverse events (all included studies)… (low certainty).

1 finding from 1 review

Intervention not reported

Non‐serious systemic adverse events (low risk of bias) live attenuated HAV vaccine ICH‐GCP 1997 · patients with preventing hepatitis A.

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Non‐serious local adverse events (all included studies) live attenuated HAV vaccine ICH‐GCP 1997 · patients with preventing hepatitis A.

The review found no eligible studies for this question.

1 finding from 1 review

Non‐invasive brain stimulation and pharmacological intervention (combination) vs a pharmacological intervention and sham stimulation or usual care (single)

Adverse events: all ‐ central nervous system events (e.g. headache, seizures) (secondary outcome) · people with depression after stroke

It is very uncertain whether pharmacological intervention and non‐invasive brain stimulation… changes adverse events: all ‐ central nervous system events (e.g. headache,… compared with a pharmacological intervention and sham stimulation or usual care… (very low certainty).

1 finding from 1 review