Findings

What do systematic reviews say?

4 questions · 4 findings · 3 reviews · Kidney and Transplant

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 4 · 100%Moderate 0 · 0%High 0 · 0%

Adverse events: death · minimal change disease in adults with nephrotic syndrome

Mycophenolate sodium + oral steroids showed no clear difference in adverse events: death compared with oral steroids alone (low certainty).

1 finding from 1 review

Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
RR 0.67 [0.12, 3.84]
1 study · 116 participants
Low

Adverse events: death · idiopathic steroid‐resistant nephrotic syndrome in children

Calcineurin inhibitor showed no clear difference in adverse events: death compared with IV cyclophosphamide (low certainty).

1 finding from 1 review

Interventions for idiopathic steroid‐resistant nephrotic syndrome in children 2019 · Cochrane Headline outcomes only
RR 0.33 [0.01, 7.92]
1 study · 131 participants
Low

Adverse events: death (all causes) · idiopathic steroid‐resistant nephrotic syndrome in children

Oral cyclophosphamide showed no clear difference in adverse events: death (all causes) compared with prednisone or placebo (low certainty).

1 finding from 1 review

Interventions for idiopathic steroid‐resistant nephrotic syndrome in children 2019 · Cochrane Headline outcomes only
RR 1.07 [0.19, 5.95]
1 study · 60 participants
Low

Adverse event causing death or study drug discontinuation · adults with renal vasculitis for maintenance therapy

Azathioprine showed no clear difference in adverse events causing death or study drug discontinuation compared with methotrexate (low certainty).

1 finding from 1 review

Interventions for renal vasculitis in adults 2020 · Cochrane Headline outcomes only
RR 0.58 [0.25, 1.38]
1 study · 126 participants
Low