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Evidence found and GRADE certainty

4 questions · 4 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 50%High 2 · 50%

Lithium vs valproate

Adverse event: tremor · acute mania

Lithium leads to higher adverse event: tremor compared with valproate (high certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 10.51 [1.96, 56.48]
    2 studies · 449 participants
    High

Lithium vs lamotrigine

Adverse event: tremor · acute mania

Lithium showed no clear difference in adverse event: tremor compared with lamotrigine (moderate certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 1.28 [0.48, 3.41]
    2 studies · 272 participants
    Moderate

Lithium vs placebo

Adverse event: tremor · acute mania

Lithium leads to higher adverse event: tremor compared with placebo (high certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 3.25 [2.1, 5.04]
    6 studies · 1241 participants
    High

Lithium vs ARIPIPRAZOLE

Adverse event: tremor · acute mania

Lithium showed no clear difference in adverse events: tremor compared with aripiprazole (moderate certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 1.45 [0.65, 3.24]
    1 study · 313 participants
    Moderate