Findings

What do systematic reviews say?

7 questions · 8 findings · 3 reviews

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No studies found 3 · 37.5%GRADE not reported 1 · 12.5%Very low 1 · 12.5%Low 1 · 12.5%Moderate 2 · 25%High 0 · 0%

CLOZAPINE vs Typical antipsychotics

Weight gain · patients with schizophrenia

CLOZAPINE probably leads to higher adverse effects 5. Weight gain compared with TYPICAL ANTIPSYCHOTICS (moderate certainty).

2 findings from 1 review

Clozapine versus typical neuroleptic medication for schizophrenia 2009 · Cochrane Headline outcomes only
RR 1.33 [1.11, 1.59]
3 studies · 484 participants
Moderate
Clozapine versus typical neuroleptic medication for schizophrenia 2009 · Cochrane Headline outcomes only
RR 1.28 [1.07, 1.53]
5 studies · 590 participants
Moderate

CLOZAPINE + RISPERIDONE vs CLOZAPINE + SULPIRIDE (Kong 2001)

Weight gain · people with treatment‐resistant schizophrenia

It is very uncertain whether CLOZAPINE + RISPERIDONE changes adverse effects: weight gain compared with CLOZAPINE + SULPIRIDE (Kong 2001) (very low certainty).

1 finding from 1 review

Clozapine combined with different antipsychotic drugs for treatment‐resistant schizophrenia 2017 · Cochrane Headline outcomes only
RR 0.4 [0.08, 1.9]
1 study · 60 participants
Very low

CLOZAPINE + RISPERIDONE vs CLOZAPINE + ZIPRASIDONE (Kuwilsky 2010)

Weight gain · people with treatment‐resistant schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Clozapine combined with different antipsychotic drugs for treatment‐resistant schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CLOZAPINE + ZIPRASIDONE vs CLOZAPINE + QUETIAPINE (Wen 2015)

Weight gain · people with treatment‐resistant schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Clozapine combined with different antipsychotic drugs for treatment‐resistant schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CLOZAPINE + ARIPIPRAZOLE vs CLOZAPINE + HALOPERIDOL (Cipriani 2013)

Weight gain · people with treatment‐resistant schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Clozapine combined with different antipsychotic drugs for treatment‐resistant schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CLOZAPINE + AMISULPIRIDE vs CLOZAPINE + QUETIAPINE (Genc 2007)

Weight gain · people with treatment‐resistant schizophrenia

1 finding from 1 review

Clozapine combined with different antipsychotic drugs for treatment‐resistant schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1 participants
GRADE not reported

QUETIAPINE vs CLOZAPINE ‐ all data short term

Weight gain · schizophrenia

QUETIAPINE showed no clear difference in adverse effects: 3. Metabolic ‐ weight gain compared with CLOZAPINE ‐ all data short term (low certainty).

1 finding from 1 review

Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
RR 0.53 [0.25, 1.11]
2 studies · 135 participants
Low