Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews · Oral medicine and oral cancer

No studies found 0 · 0%GRADE not reported 2 · 33.3%Very low 3 · 50%Low 1 · 16.7%Moderate 0 · 0%High 0 · 0%

Adverse effects · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether topical corticosteroid changes adverse effects compared with placebo (very low certainty).

1 finding from 1 review

Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes
3-9 weeks
RR 1.48 [0.48, 4.56]
3 studies · 88 participants
Very low

Adverse effects · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether topical clobetasol propionate changes adverse effects compared with topical tacrolimus (very low certainty).

1 finding from 1 review

Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes
3-8 weeks
RR 0.05 [0.00, 0.83]
2 studies · 100 participants
Very low

Adverse effects · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether topical clobetasol propionate changes adverse effects compared with topical ciclosporin (very low certainty).

1 finding from 1 review

Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes
3-8 weeks
RR 6.32 [0.84, 47.69]
1 study · 39 participants
Very low

Adverse effects · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical triamcinolone acetonide showed no clear difference in adverse effects compared with topical pimecrolimus; GRADE not reported.

1 finding from 1 review

Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes
end of treatment
RR 0.21 [0.01, 4.10]
1 study · 35 participants
GRADE not reported

Adverse effects · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical triamcinolone acetonide may leads to lower adverse effects compared with topical tacrolimus (low certainty).

1 finding from 1 review

Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes
3-8 weeks
RR 0.47 [0.22, 0.99]
2 studies · 58 participants
Low

Adverse effects · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical triamcinolone acetonide led to lower adverse effects compared with topical ciclosporin; GRADE not reported.

1 finding from 1 review

Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes
end of treatment
RR 0.15 [0.05, 0.49]
1 study · 139 participants
GRADE not reported