What do systematic reviews say?

Tetracycline suspension (250 mg, held in mouth 2 minutes then swallowed, four times daily for 5 days) vs placebo

• Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes

  5 days per outbreak
  Adverse event rates were comparable between groups.
  1 study
  GRADE not reported

Oral azithromycin vs topical tetracycline

• Antibiotics for trachoma 2019 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 6002 participants
  GRADE not reported

HP paint-on gel vs HP paint-on gel

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Tooth sensitivity in both groups with no evidence of a difference (Ziebolz 2008)
  1 study
  GRADE not reported

HP gel in tray vs placebo

The review found no eligible studies for this question.

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Not reported
  Studies not reported
  No studies found

HP mouthwash vs placebo

The review found no eligible studies for this question.

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Not reported
  Studies not reported
  No studies found

CP paint-on gel vs placebo

The review found no eligible studies for this question.

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Not reported
  Studies not reported
  No studies found

CP gel in tray vs placebo

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Main adverse events reported in majority of trials were mild and transient tooth sensitivity and oral irritation which occurred more in the intervention group compared to placebo
  3 studies
  GRADE not reported

HP strips vs HP gel in tray

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Tooth sensitivity and oral irritation mild and transient and did not differ between groups
  2 studies
  GRADE not reported

HP paint-on gel vs HP strips

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Adverse events mild; slightly higher tooth hypersensitivity and gingival irritation in strip group but no evidence of a difference
  2 studies
  GRADE not reported

SHMP chewing gum vs placebo

The review found no eligible studies for this question.

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Not reported
  Studies not reported
  No studies found

CP paint-on gel vs HP paint-on gel

The review found no eligible studies for this question.

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Not reported
  Studies not reported
  No studies found

CP paint-on gel vs CP paint-on gel

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Very mild tooth sensitivity in the 4x/day group; gingival and tooth sensitivity transient, none withdrew
  2 studies
  GRADE not reported

CP gel in tray vs CP gel in tray

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Higher concentrations of CP in tray led to more tooth sensitivity and gingival irritation; symptoms mild and transient; CP with desensitiser showed significantly less sensitivity
  4 studies
  GRADE not reported

HP strips vs CP gel in tray

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Results variable for tooth sensitivity and oral irritation, some favouring strip, some tray, some no difference
  7 studies
  GRADE not reported

SPC paint-on gel vs CP paint-on gel

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  One subject in 19% SPC group reported oral sensitivity; all adverse events mild (Barlow 2003)
  1 study
  GRADE not reported

SPC paint-on gel vs HP strips

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Tooth sensitivity and oral irritation most common adverse events with strip use; symptomatic only (Bizhang 2007)
  1 study
  GRADE not reported

HP paint-on gel vs placebo

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  HP group had more gum irritation (reddening) than placebo though mild; one case of tooth sensitivity (Collins 2004a)
  1 study
  GRADE not reported

HP strips vs 2% HP mouthwash/rinse

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Tooth sensitivity and oral irritation more common in strip group; all mild (Gerlach 2005)
  1 study
  GRADE not reported

CP paint-on gel vs HP strips

The review found no eligible studies for this question.

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Not reported
  Studies not reported
  No studies found

HP strips vs placebo

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Mild and transient tooth sensitivity and oral irritation were the most common adverse events reported in most of the trials
  7 studies
  GRADE not reported