What do systematic reviews say?

Lutein with or without zeaxanthin vs placebo

It is very uncertain whether lutein with or without zeaxanthin changes adverse effects compared with placebo (very low certainty).

• Antioxidant vitamin and mineral supplements for slowing the progression of age‐related macular degeneration 2023 · Cochrane Headline outcomes only
  OR 1.06
  Studies not reported
  Very low

Vitamin E vs placebo

It is very uncertain whether vitamin E changes adverse effects compared with placebo (very low certainty).

• Antioxidant vitamin and mineral supplements for slowing the progression of age‐related macular degeneration 2023 · Cochrane Headline outcomes only
  no estimate extracted
  4 participants
  Very low

Zinc vs placebo

• Antioxidant vitamin and mineral supplements for slowing the progression of age‐related macular degeneration 2023 · Cochrane Headline outcomes only
  no estimate extracted
  286 participants
  Very low

Antioxidant multivitamin and mineral supplement vs placebo or no treatment

Antioxidant multivitamin and mineral supplement may leads to lower adverse effects compared with placebo or no treatment (low certainty).

• Antioxidant vitamin and mineral supplements for slowing the progression of age‐related macular degeneration 2023 · Cochrane Headline outcomes only
  OR 0.87
  0 participants
  Low

Intervention not reported

The review found no eligible studies for this question.

• Interventions to slow progression of myopia in children 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Omega‐3 vs placebo

Omega 3 fatty acids leads to higher adverse effects compared with placebo (high certainty).

• Omega 3 fatty acids for preventing or slowing the progression of age‐related macular degeneration 2015 · Cochrane Headline outcomes only
  RR 1.01
  2 studies · 2343 participants
  High