What do systematic reviews say?

Transdermal beta‐estradiol gel vs placebo

• Bioidentical hormones for women with vasomotor symptoms 2016 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 1086 participants
  Moderate

Desloratadine 5 to 20 mg vs placebo

Desloratadine 5 to 20 mg showed no clear difference in adverse effects leading to withdrawal: intermediate‐term duration of… compared with placebo (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1.46 [0.42, 5.1]
  3 studies · 466 participants
  Low

STANDARD LOWER DOSE (> 3 to 7.5 mg/day) vs OTHER DOSES

It is very uncertain whether STANDARD LOWER DOSE (> 3 to 7.5 mg/day) changes adverse effects: 1. Clinically significant extrapyramidal side… compared with OTHER DOSES (very low certainty).

• Haloperidol dose for the acute phase of schizophrenia 2013 · Cochrane Headline outcomes only
  RR 0.59 [0.45, 0.78]
  3 studies · 144 participants
  Very low

Cetirizine 0.5 mg/kg/d vs placebo (18‐month intervention)

Cetirizine 0.5 mg/kg/d showed no clear difference in primary outcome 2. Proportion of participants reporting adverse… compared with placebo (18‐month intervention) (moderate certainty).

• Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema 2019 · Cochrane Headline outcomes only
  RR 0.68 [0.46, 1.01]
  1 study · 795 participants
  Moderate

STANDARD LOWER DOSE (> 3 to 7.5 mg/day) vs OTHER DOSES

It is very uncertain whether STANDARD LOWER DOSE (> 3 to 7.5 mg/day) changes adverse effects: 1. Clinically significant extrapyramidal side… compared with OTHER DOSES (very low certainty).

• Haloperidol dose for the acute phase of schizophrenia 2013 · Cochrane Headline outcomes only
  RR 0.12 [0.01, 2.12]
  2 studies · 64 participants
  Very low