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What do systematic reviews say?

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Evidence found and GRADE certainty

49 questions · 49 findings · 26 reviews

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No studies found 13 · 26.5%GRADE not reported 6 · 12.2%Very low 13 · 26.5%Low 10 · 20.4%Moderate 7 · 14.3%High 0 · 0%

Antibiotics vs control

Adverse effects · people (any age) with active trachoma

Antibiotic may leads to lower adverse effects compared with control (low certainty).

1 finding from 1 review

Antistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) vs broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all outcomes

Maternal composite adverse effects · women undergoing caesarean section

It is very uncertain whether antistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) changes maternal composite adverse effects compared with broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all… (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse effects: gastrointestinal bleeding · children and adults with acute bacterial meningitis

The intervention showed no clear difference in adverse effects: gastrointestinal bleeding (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse effects: nausea, vomiting, diarrhoea · children and adults with acute bacterial meningitis

It is very uncertain whether the intervention changes adverse effects: nausea, vomiting, diarrhoea (very low certainty).

1 finding from 1 review

Summary of findings ‐ withdrawal of penicillin prophylaxis vs continuation

Nausea and vomiting · children with SCD who have been receiving prophylactic penicillin for at least two years

Summary of findings ‐ withdrawal of penicillin prophylaxis showed no clear difference in adverse effects: incidences of nausea and vomiting compared with continuation (low certainty).

1 finding from 1 review