Findings

What do systematic reviews say?

4 questions · 4 findings · 2 reviews · Oral Health

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No studies found 0 · 0%GRADE not reported 1 · 25%Very low 3 · 75%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Antidepressants (trazodone 200 mg/day) vs placebo

Adverse effects: headache · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether antidepressants (trazodone 200 mg/day) changes adverse effects: headache compared with placebo (very low certainty).

1 finding from 1 review

Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes
short-term (up to 3 months)
RR 1.58 [0.30, 8.40]
1 study · 37 participants
Very low

Dietary supplements (alpha lipoic acid +/- adjunctive ingredients) vs placebo

Adverse effects: headache · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether dietary supplements (alpha lipoic acid +/- adjunctive ingredients) changes adverse effects: headache compared with placebo (very low certainty).

1 finding from 1 review

Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes
short-term (up to 3 months)
RR 10.87 [1.36, 87.03]
2 studies · 118 participants
Very low

Anticonvulsants (gabapentin + alpha lipoic acid) vs placebo

Adverse effects: mild headache · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether anticonvulsants (gabapentin + alpha lipoic acid) changes adverse effects: mild headache compared with placebo (very low certainty).

1 finding from 1 review

Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes
short-term (up to 3 months) · gabapentin with adjunctive ALA
RR 8.71 [0.37, 205.80]
1 study · 80 participants
Very low

Light vibrational forces (LVF) vs Conventional orthodontic appliance treatment

Harms: non-serious adverse effects (headache, discomfort, loosening of temporary anchorage devices) · Adolescents and adults with malocclusion undergoing orthodontic treatment with fixed or removable appliances

Light vibrational forces (LVF) showed no clear difference in harms: non-serious adverse effects (headache, discomfort, loosening… compared with conventional orthodontic appliance treatment (placebo or no adjunct); GRADE not reported.

1 finding from 1 review

Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment 2023 · Cochrane All outcomes
RR 0.96 [0.32, 2.85]
1 study · 45 participants
GRADE not reported