Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 50%Moderate 0 · 0%High 1 · 50%

Adverse effects: dry mouth · otherwise healthy adults and children with common cold symptoms

Antihistamine‐decongestant leads to higher adverse effects: dry mouth compared with placebo (high certainty).

1 finding from 1 review

Oral antihistamine‐decongestant‐analgesic combinations for the common cold 2022 · Cochrane Headline outcomes only
OR 3.75 [1.74, 8.1]
4 studies · 640 participants
High

Adverse effects: dry mouth · otherwise healthy adults and children with common cold symptoms

Analgesic‐decongestant showed no clear difference in adverse effects: dry mouth compared with placebo (low certainty).

1 finding from 1 review

Oral antihistamine‐decongestant‐analgesic combinations for the common cold 2022 · Cochrane Headline outcomes only
OR 1.43 [0.53, 3.83]
3 studies · 764 participants
Low