Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 50%Moderate 1 · 50%High 0 · 0%

Adverse effects: SPRM‐associated endometrial changes · uterine fibroids

SPRM probably leads to higher adverse effects: SPRM‐associated endometrial changes compared with leuprolide acetate (moderate certainty).

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
OR 10.45 [5.38, 20.33]
1 study · 301 participants
Moderate

Adverse effects: SPRM‐associated endometrial changes · women with uterine fibroids

SPRM may leads to higher adverse effects: SPRM‐associated endometrial changes compared with placebo (low certainty).

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
OR 15.12 [6.45, 35.47]
5 studies · 405 participants
Low