What do systematic reviews say?

ZOTEPINE vs REMOXIPRIDE

ZOTEPINE showed no clear difference in adverse effects: Extrapyramidal effects ‐ use of antiparkinson… compared with REMOXIPRIDE (low certainty).

• Zotepine versus other atypical antipsychotics for schizophrenia 2010 · Cochrane Headline outcomes only
  RR 0.97 [0.41, 2.29]
  1 study · 49 participants
  Low

ZOTEPINE vs CLOZAPINE

It is very uncertain whether ZOTEPINE changes adverse effects: Extrapyramidal effects ‐ use of antiparkinson… compared with CLOZAPINE (very low certainty).

• Zotepine versus other atypical antipsychotics for schizophrenia 2010 · Cochrane Headline outcomes only
  RR 20.96 [2.89, 151.9]
  2 studies · 116 participants
  Very low

QUETIAPINE vs PALIPERIDONE

QUETIAPINE probably leads to lower adverse effects: 2. Extrapyramidal effects use of antiparkinson… compared with PALIPERIDONE (moderate certainty).

• Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
  RR 0.64 [0.45, 0.91]
  1 study · 319 participants
  Moderate

QUETIAPINE vs CLOZAPINE ‐ all data short term

• Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 28 participants
  Low

QUETIAPINE vs OLANZAPINE

• Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 1127 participants
  Moderate

QUETIAPINE vs RISPERIDONE

QUETIAPINE probably leads to lower adverse effects: 2. Extrapyramidal effects ‐ use of antiparkinson… compared with RISPERIDONE (moderate certainty).

• Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
  RR 0.5 [0.36, 0.69]
  8 studies · 2163 participants
  Moderate

QUETIAPINE vs ZIPRASIDONE

QUETIAPINE may leads to lower adverse effects: 2. Extrapyramidal effects ‐ use of antiparkinson… compared with ZIPRASIDONE (low certainty).

• Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
  RR 0.43 [0.2, 0.93]
  1 study · 522 participants
  Low

QUETIAPINE vs ARIPIPRAZOLE

QUETIAPINE showed no clear difference in adverse effects: 2. Extrapyramidal effects ‐ use of antiparkinson… compared with ARIPIPRAZOLE (low certainty).

• Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
  RR 0.67 [0.12, 3.57]
  1 study · 40 participants
  Low

ZOTEPINE vs RISPERIDONE

It is very uncertain whether ZOTEPINE changes adverse effects: Extrapyramidal effects ‐ use of antiparkinson… compared with RISPERIDONE (very low certainty).

• Zotepine versus other atypical antipsychotics for schizophrenia 2010 · Cochrane Headline outcomes only
  RR 6 [0.79, 45.42]
  1 study · 40 participants
  Very low

ZOTEPINE vs RISPERIDONE

It is very uncertain whether ZOTEPINE changes adverse effects: Extrapyramidal effects ‐ use of antiparkinson… compared with RISPERIDONE (very low certainty).

• Zotepine versus other atypical antipsychotics for schizophrenia 2010 · Cochrane Headline outcomes only
  RR 3 [0.69, 13.12]
  1 study · 40 participants
  Very low