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What do systematic reviews say?

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Evidence found and GRADE certainty

5 questions · 5 findings · 4 reviews · Haematology

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 60%Moderate 2 · 40%High 0 · 0%

Summary of findings table ‐ Convalescent plasma vs placebo or usual care

Admission to hospital or death within 28 days · outpatients withmild disease

Summary of findings table ‐ Convalescent plasma showed no clear difference in admission to hospital or death within 28 days compared with placebo or standard care alone (low certainty).

1 finding from 1 review

Summary of findings table ‐ Convalescent plasma vs standard plasma

Admission to hospital or death within 28 days · outpatients withmild disease

Summary of findings table ‐ Convalescent plasma probably leads to lower admission to hospital or death within 28 days compared with standard plasma (moderate certainty).

1 finding from 1 review

Azithromycin vs placebo or usual care

Admission to hospital or death within 28 days · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

Azithromycin showed no clear difference in admission to hospital or death within 28 days compared with placebo or standard of care alone (low certainty).

1 finding from 1 review

Intervention not reported

Worsening of clinical status: admission to hospital or death within 28 days · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

The intervention showed no clear difference in worsening of clinical status: admission to hospital or death within… (low certainty).

1 finding from 1 review