Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Epilepsy

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No studies found 3 · 42.9%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 28.6%Moderate 2 · 28.6%High 0 · 0%

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam/intravenous phenytoin combination

Additional drugs required to stop the seizure · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intravenous lorazepam showed no clear difference in additional drugs required to stop the seizure compared with intravenous diazepam/intravenous phenytoin combination (moderate certainty).

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
RR 0.42 [0.17, 1.04]
1 study · 178 participants
Moderate

Summary of findings ‐ Buccal midazolam vs intravenous diazepam

Additional drugs required to stop the seizure · Children with acute tonic‐clonic seizures

The review found no eligible studies for this question.

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Intranasal midazolam vs intravenous diazepam

Additional drugs required to stop the seizure · Children with acute tonic‐clonic seizures

The review found no eligible studies for this question.

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Intranasal midazolam vs rectal diazepam

Additional drugs required to stop the seizure · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intranasal midazolam showed no clear difference in additional drugs required to stop the seizure compared with rectal diazepam (low certainty).

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
RR 0.32 [0.1, 1.03]
1 study · 45 participants
Low

Summary of findings ‐ Intramuscular midazolam vs rectal diazepam

Additional drugs required to stop the seizure · Children with acute tonic‐clonic seizures

The review found no eligible studies for this question.

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Buccal midazolam vs rectal diazepam

Additional drugs required to stop the seizure: intravenous lorazepam required · Children with acute tonic‐clonic seizures

Summary of findings ‐ Buccal midazolam may leads to lower additional drugs required to stop the seizure: intravenous lorazepam… compared with rectal diazepam (low certainty).

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
RR 0.58 [0.42, 0.79]
1 study · 177 participants
Low

Intravenous midazolam vs intravenous diazepam

Additional drugs required to stop the seizure: additional dose of the trial drug required · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intravenous midazolam showed no clear difference in additional drugs required to stop the seizure: additional dose of… compared with intravenous diazepam (moderate certainty).

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
RR 0.25 [0.03, 2.14]
1 study · 80 participants
Moderate