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What do systematic reviews say?

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Evidence found and GRADE certainty

7 questions · 7 findings · 1 reviews · Headline outcomes only

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No studies found 3 · 42.9%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 28.6%Moderate 2 · 28.6%High 0 · 0%

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam/intravenous phenytoin combination

Additional drugs required to stop the seizure · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intravenous lorazepam showed no clear difference in additional drugs required to stop the seizure compared with intravenous diazepam/intravenous phenytoin combination (moderate certainty).

1 finding from 1 review

Summary of findings ‐ Intranasal midazolam vs rectal diazepam

Additional drugs required to stop the seizure · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intranasal midazolam showed no clear difference in additional drugs required to stop the seizure compared with rectal diazepam (low certainty).

1 finding from 1 review

Summary of findings ‐ Buccal midazolam vs rectal diazepam

Additional drugs required to stop the seizure: intravenous lorazepam required · Children with acute tonic‐clonic seizures

Summary of findings ‐ Buccal midazolam may leads to lower additional drugs required to stop the seizure: intravenous lorazepam… compared with rectal diazepam (low certainty).

1 finding from 1 review

Intravenous midazolam vs intravenous diazepam

Additional drugs required to stop the seizure: additional dose of the trial drug required · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intravenous midazolam showed no clear difference in additional drugs required to stop the seizure: additional dose of… compared with intravenous diazepam (moderate certainty).

1 finding from 1 review