Findings

What do systematic reviews say?

25 questions · 25 findings · 1 reviews

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No studies found 7 · 28%GRADE not reported 0 · 0%Very low 2 · 8%Low 10 · 40%Moderate 5 · 20%High 1 · 4%

Summary of findings: Protein supplements vs no intervention

Acute and late GI toxicity (grade 2+) · People undergoing RT for pelvic cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Superoxide dismutase (SOD) vs no intervention

Acute and late GI toxicity (grade 2+) · people with Rectal Cancer

Summary of findings: Superoxide dismutase may leads to lower acute and late GI toxicity (grade 2+) compared with no intervention (low certainty).

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
RR 0.2 [0.05, 0.86]
1 study · 92 participants
Low

Summary of findings: Higher bladder volume vs lower bladder volume

Acute and late GI toxicity (grade 2+) · Men undergoing RT for prostate cancer

Summary of findings: Higher bladder volume showed no clear difference in acute and late GI toxicity (grade 2+) compared with lower bladder volume (low certainty).

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
RR 2.22 [0.62, 7.93]
1 study · 110 participants
Low

Summary of findings: Bile acid sequestrants vs no intervention

Acute and late GI toxicity (grade 2+) · People with pelvic cancer

Summary of findings: Bile acid sequestrants may leads to higher acute and late GI toxicity (grade 2+) compared with no intervention (low certainty).

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
RR 4.24 [1.07, 16.7]
1 study · 33 participants
Low

Sucralfate vs placebo

Acute and late GI toxicity (grade 2+) · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer

Summary of findings: Sucralfate showed no clear difference in acute and late GI toxicity (grade 2+) [acute = during RT; late = 6… compared with placebo (moderate certainty).

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
RR 1.07 [0.83, 1.39]
1 study · 335 participants
Moderate