Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

10 questions · 10 findings · 1 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

No studies found 2 · 20%GRADE not reported 0 · 0%Very low 1 · 10%Low 3 · 30%Moderate 4 · 40%High 0 · 0%

Summary of findings: Proteolytic enzymes vs placebo or control

Acute and late GI toxicity (grade 2+) · People undergoing RT for pelvic cancer

Summary of findings: Proteolytic enzymes may leads to lower acute and late GI toxicity (grade 2+) compared with control (placebo or no intervention) (low certainty).

1 finding from 1 review

Summary of findings: Aminosalicylates vs placebo

Acute and late GI toxicity (grade 2+) · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer

Summary of findings: Aminosalicylates probably leads to higher acute and late GI toxicity (grade 2+) compared with placebo (moderate certainty).

1 finding from 1 review

Summary of findings: Sodium butyrate vs placebo

Acute and late GI toxicity (grade 2+) · Men undergoing RT for prostate cancer

Summary of findings: Sodium butyrate showed no clear difference in acute and late GI toxicity (grade 2+) compared with placebo (moderate certainty).

1 finding from 1 review

Sucralfate vs placebo

Acute and late GI toxicity (grade 2+) · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer

Summary of findings: Sucralfate showed no clear difference in acute and late GI toxicity (grade 2+) [acute = during RT; late = 6… compared with placebo (moderate certainty).

1 finding from 1 review