Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews · Common Mental Disorders

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 33.3%Low 2 · 66.7%Moderate 0 · 0%High 0 · 0%

S‐adenosyl methionine as monotherapy vs SSRI

Secondary outcome: acceptability of treatment · depression in adults

S‐adenosyl methionine as monotherapy showed no clear difference in acceptability Participants dropping out of treatment during the… compared with SSRI antidepressant agent (low certainty).

1 finding from 1 review

S‐adenosyl methionine (SAMe) for depression in adults 2016 · Cochrane Headline outcomes only
RR 0.81 [0.57, 1.16]
1 study · 129 participants
Low

S‐adenosyl methionine as monotherapy vs placebo

Secondary outcome: acceptability of treatment · depression in adults

S‐adenosyl methionine as monotherapy showed no clear difference in acceptability Participants dropping out of treatment during the… compared with placebo (low certainty).

1 finding from 1 review

S‐adenosyl methionine (SAMe) for depression in adults 2016 · Cochrane Headline outcomes only
RR 0.88 [0.61, 1.29]
2 studies · 142 participants
Low

S‐adenosyl methionine as monotherapy vs tricyclic antidepressants (TCAs)

Secondary outcome: acceptability of treatment · depression in adults

It is very uncertain whether S‐adenosyl methionine as monotherapy changes acceptability Participants dropping out of treatment during the… compared with tricyclic antidepressant agent (very low certainty).

1 finding from 1 review

S‐adenosyl methionine (SAMe) for depression in adults 2016 · Cochrane Headline outcomes only
RR 0.61 [0.28, 1.31]
3 studies · 78 participants
Very low