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What do systematic reviews say?

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Evidence found and GRADE certainty

2 questions · 2 findings · 2 reviews · Oral medicine and oral cancer

No studies found 0 · 0%GRADE not reported 2 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Tongue scraper or tongue cleaner (One Drop Only tongue cleaner; Tongue-Putzer scraper; polystyrene scraper) vs Toothbrush (used to clean the tongue)

Adverse effects (tongue trauma, nausea) and acceptability · Adults (over 18 years) with a clinical or self-assessed diagnosis of halitosis
1 finding from 1 review
  • Tongue scraping for treating halitosis 2006 · Cochrane All outcomes
    1 week (Pedrazzi 2004)
    Pedrazzi 2004: six of ten (60%) participants complained of nausea and one participant of tongue trauma, only with the toothbrush; all participants were receptive to the tongue scraper. Seemann 2001: no adverse effects…
    2 studies
    GRADE not reported

Systemic oral acyclovir vs placebo or no treatment

Patient or parental satisfaction (tolerance and acceptability of drug) · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)
1 finding from 1 review
  • Amir 1997b: no data available. Ducoulombier 1988: tolerance and acceptability of the drug was described as satisfactory, but it was unclear how this was assessed by the trialists.
    1 study
    GRADE not reported