Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

269 questions · 274 findings · 100 reviews

No studies found 58 · 21.2%GRADE not reported 27 · 9.9%Very low 96 · 35%Low 53 · 19.3%Moderate 32 · 11.7%High 8 · 2.9%

Primary objective: mobile stock notification with enhanced management vs usual care

Provider acceptability and satisfaction (Proportion of participants who reported using the digital intervention) · healthcare workers and other health professionals involved in commodity and stock management
1 finding from 1 review

Topiramate as add‐on therapy vs alternative drug

Acceptability. Participants experiencing troublesome adverse effects of any nature · adults with acute affective episodes in bipolar disorder

It is very uncertain whether topiramate as add‐on therapy changes acceptability with topiramate (8 weeks) Number of participants… compared with alternative drug (very low certainty).

1 finding from 1 review

Topiramate as monotherapy vs alternative drug

Acceptability. Participants experiencing troublesome adverse effects of any nature · adults with acute affective episodes in bipolar disorder

Topiramate as monotherapy showed no clear difference in acceptability with topiramate (12 weeks) Number of participants… compared with an alternative drug (low certainty).

1 finding from 1 review

Topiramate as add‐on therapy vs placebo

Acceptability. Participants experiencing troublesome adverse effects of any nature · adults with acute affective episodes in bipolar disorder

Topiramate as add‐on therapy showed no clear difference in acceptability with topiramate (endpoint: 12 weeks) Number of… compared with placebo (low certainty).

1 finding from 1 review

Topiramate vs placebo

Acceptability. Participants experiencing troublesome adverse effects of any nature · adults with acute affective episodes in bipolar disorder

Topiramate showed no clear difference in acceptability with topiramate (endpoint: 12 weeks) Number of… compared with placebo (low certainty).

1 finding from 1 review