Findings

What do systematic reviews say?

9 questions · 9 findings · 2 reviews · Headline outcomes only

No studies found 1 · 11.1%GRADE not reported 0 · 0%Very low 5 · 55.6%Low 2 · 22.2%Moderate 1 · 11.1%High 0 · 0%

Acceptability ‐ total dropouts · adults (aged 18 years+) with depression in bipolar disorder

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 16 participants
Very low

Acceptability ‐ total dropouts · adults (aged 18 years+) with depression in bipolar disorder

Memantine showed no clear difference in acceptability: total dropouts compared with placebo (low certainty).

1 finding from 1 review

Acceptability ‐ total dropouts · adults (aged 18 years+) with depression in bipolar disorder

It is very uncertain whether cytidine changes acceptability: total dropouts compared with placebo (very low certainty).

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
OR 0.94 [0.12, 7.52]
1 study · 35 participants
Very low

Acceptability ‐ total dropouts · adults (aged 18 years+) with depression in bipolar disorder

It is very uncertain whether riluzole changes acceptability: total dropouts compared with placebo (very low certainty).

1 finding from 1 review

Acceptability ‐ total dropouts · adults (aged 18 years+) with depression in bipolar disorder

It is very uncertain whether ketamine changes acceptability: total dropouts compared with placebo (very low certainty).

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
OR 3.48 [0.56, 21.74]
2 studies · 33 participants
Very low

Dropout · adults (aged 18 years+) with depression in bipolar disorder

The review found no eligible studies for this question.

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Acceptability ‐ total dropouts · adults with Major Depressive Disorder

Ketamine showed no clear difference in acceptability: total dropouts№ of participants: 72(1 RCT) compared with midazolam (low certainty).

1 finding from 1 review

Acceptability ‐ total dropouts · adults with Major Depressive Disorder

Esketamine showed no clear difference in acceptability: total dropouts№ of participants: 773(5 RCTs) compared with placebo (moderate certainty).

1 finding from 1 review

Acceptability ‐ total dropouts · adults with Major Depressive Disorder

It is very uncertain whether ketamine changes acceptability: total dropouts№ of participants: 201(6 RCTs) compared with placebo (very low certainty).

1 finding from 1 review