What do systematic reviews say?

Memantine vs placebo

Memantine showed no clear difference in acceptability: total dropouts compared with placebo (low certainty).

• Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
  OR 0.77 [0.45, 1.31]
  2 studies · 261 participants
  Low