What do systematic reviews say?

Ketamine vs placebo

It is very uncertain whether ketamine changes acceptability: total dropouts№ of participants: 201(6 RCTs) compared with placebo (very low certainty).

• Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive disorder 2021 · Cochrane Headline outcomes only
  OR 1.25 [0.19, 8.28]
  Studies not reported
  Very low