Findings

What do systematic reviews say?

7 questions · 7 findings · 2 reviews

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No studies found 6 · 85.7%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%

Memantine vs placebo

Acceptability ‐ dropouts due to adverse effects · adults (aged 18 years+) with depression in bipolar disorder

Memantine showed no clear difference in acceptability: dropouts due to adverse effects compared with placebo (low certainty).

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
OR 0.34 [0.01, 8.34]
1 study · 232 participants
Low

Cytidine vs placebo

Acceptability ‐ dropouts due to adverse effects · adults (aged 18 years+) with depression in bipolar disorder

The review found no eligible studies for this question.

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Ketamine vs placebo

Acceptability ‐ dropouts due to adverse effects · adults (aged 18 years+) with depression in bipolar disorder

The review found no eligible studies for this question.

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

N‐acetylcysteine vs placebo

Withdrawals due to adverse events · adults (aged 18 years+) with depression in bipolar disorder

The review found no eligible studies for this question.

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Riluzole vs placebo

Withdrawals due to adverse events · adults (aged 18 years+) with depression in bipolar disorder

The review found no eligible studies for this question.

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Esketamine vs placebo

Withdrawals due to adverse events · adults with Major Depressive Disorder

The review found no eligible studies for this question.

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive disorder 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Ketamine vs placebo

Withdrawals due to adverse events · adults with Major Depressive Disorder

The review found no eligible studies for this question.

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive disorder 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found