What do systematic reviews say?

Topiramate vs placebo

Topiramate leads to higher 50% or greater reduction in seizure frequency (ITT analysis) compared with placebo (high certainty).

• Topiramate add‐on therapy for drug‐resistant focal epilepsy 2019 · Cochrane Headline outcomes only
  RR 2.71 [2.05, 3.59]
  12 studies · 1650 participants
  High