Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 20%Moderate 4 · 80%High 0 · 0%

Ataxia · people with focal epilepsy

Zonisamide may leads to higher adverse effects: ataxia (whole treatment period; any dose) compared with placebo (low certainty).

1 finding from 1 review

Zonisamide add‐on therapy for focal epilepsy 2020 · Cochrane Headline outcomes only
RR 3.85
4 studies · 734 participants
Low

Nausea · people with focal epilepsy

Zonisamide probably leads to higher adverse effects: nausea (whole treatment period; any dose) compared with placebo (moderate certainty).

1 finding from 1 review

Zonisamide add‐on therapy for focal epilepsy 2020 · Cochrane Headline outcomes only
RR 1.1
5 studies · 805 participants
Moderate

Adverse effect: fatigue · people with focal epilepsy

Zonisamide probably leads to higher adverse effects: fatigue (whole treatment period; any dose) compared with placebo (moderate certainty).

1 finding from 1 review

Zonisamide add‐on therapy for focal epilepsy 2020 · Cochrane Headline outcomes only
RR 1.41
6 studies · 1045 participants
Moderate

Frequency of adverse effects ‐ dizziness ( · people with focal epilepsy

Zonisamide probably leads to higher adverse effects: dizziness (whole treatment period; any dose) compared with placebo (moderate certainty).

1 finding from 1 review

Zonisamide add‐on therapy for focal epilepsy 2020 · Cochrane Headline outcomes only
RR 1.4
7 studies · 1429 participants
Moderate

Somnolence · people with focal epilepsy

Zonisamide probably leads to higher adverse effects: somnolence (whole treatment period; any dose) compared with placebo (moderate certainty).

1 finding from 1 review

Zonisamide add‐on therapy for focal epilepsy 2020 · Cochrane Headline outcomes only
RR 1.52
8 studies · 1636 participants
Moderate