Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Pregnancy and Childbirth

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 14.3%Low 4 · 57.1%Moderate 2 · 28.6%High 0 · 0%

Zinc vs no zinc supplementation

Preterm birth · Pregnant women (healthy and probable zinc deficiency)

Zinc supplementation showed no clear difference in preterm birth (< 37 weeks) compared with no zinc (with or without placebo) (low certainty).

1 finding from 1 review

Zinc supplementation for improving pregnancy and infant outcome 2021 · Cochrane Headline outcomes only
RR 0.87 [0.74, 1.03]
21 studies · 9851 participants
Low

Zinc vs no zinc supplementation

Stillbirth · Pregnant women (healthy and probable zinc deficiency)

Zinc supplementation showed no clear difference in stillbirth compared with no zinc (with or without placebo) (low certainty).

1 finding from 1 review

Zinc supplementation for improving pregnancy and infant outcome 2021 · Cochrane Headline outcomes only
RR 1.22 [0.8, 1.88]
7 studies · 3295 participants
Low

Zinc vs no zinc supplementation

Neonatal mortality · Pregnant women (healthy and probable zinc deficiency)

It is very uncertain whether zinc supplementation changes neonatal death compared with no zinc (with or without placebo) (very low certainty).

1 finding from 1 review

Zinc supplementation for improving pregnancy and infant outcome 2021 · Cochrane Headline outcomes only
RR 2.44 [0.4, 14.83]
3 studies · 1965 participants
Very low

Zinc vs no zinc supplementation

Perinatal mortality · Pregnant women (healthy and probable zinc deficiency)

Zinc supplementation showed no clear difference in perinatal death compared with no zinc (with or without placebo) (low certainty).

1 finding from 1 review

Zinc supplementation for improving pregnancy and infant outcome 2021 · Cochrane Headline outcomes only
RR 1.1 [0.81, 1.51]
2 studies · 2489 participants
Low

Zinc vs no zinc supplementation

Birthweight (g) · Pregnant women (healthy and probable zinc deficiency)

1 finding from 1 review

Zinc supplementation for improving pregnancy and infant outcome 2021 · Cochrane Headline outcomes only
no estimate extracted
22 studies · 7977 participants
Low

Zinc vs no zinc supplementation

Small‐for‐gestational age or IUGR · Pregnant women (healthy and probable zinc deficiency)

Zinc supplementation showed no clear difference in small‐for‐gestational age or IUGR compared with no zinc (with or without placebo) (moderate certainty).

1 finding from 1 review

Zinc supplementation for improving pregnancy and infant outcome 2021 · Cochrane Headline outcomes only
RR 1.02 [0.92, 1.12]
9 studies · 5330 participants
Moderate

Zinc vs no zinc supplementation

Low birthweight · Pregnant women (healthy and probable zinc deficiency)

Zinc supplementation showed no clear difference in low Birthweight (< 2500 g) compared with no zinc (with or without placebo) (moderate certainty).

1 finding from 1 review

Zinc supplementation for improving pregnancy and infant outcome 2021 · Cochrane Headline outcomes only
RR 0.94 [0.79, 1.13]
17 studies · 7399 participants
Moderate