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Evidence found and GRADE certainty

7 questions · 7 findings · 1 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 2 · 28.6%GRADE not reported 0 · 0%Very low 5 · 71.4%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Vitamin C 1400 mg plus vitamin E 800 mg vs placebo

Severity of pain (use of opioid analgesics) · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)

It is very uncertain whether vitamin C 1400 mg plus vitamin E 800 mg changes severity of pain (use of opioid analgesics) compared with placebo (very low certainty).

1 finding from 1 review

Vitamin C 1400 mg plus vitamin E 800 mg vs placebo

Acute chest syndrome ( · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)

It is very uncertain whether vitamin C 1400 mg plus vitamin E 800 mg changes frequency of sickle cell‐related complications: acute chest syndrome compared with placebo (very low certainty).

1 finding from 1 review