Any AMD · general population
Vitamin C showed no clear difference in any AMD compared with placebo (high certainty).
1 finding from 1 review
Progression to late AMD (neovascular AMD, geographic atrophy or both) · general population
Vitamin C showed no clear difference in late AMD (either neovascular AMD or geographic atrophy or both) compared with placebo (moderate certainty).
1 finding from 1 review
Neovascular AMD · general population
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Geographic atrophy · general population
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of life · general population
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse effects · general population
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Resource use and costs · general population
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Progression to late AMD (neovascular AMD, geographic atrophy or both) · people with AMD
It is very uncertain whether vitamin E changes progression to late AMD (neovascular AMD, geographic atrophy or both) compared with placebo (very low certainty).
1 finding from 1 review
Progression to neovascular AMD · people with AMD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Progression to geographic atrophy · people with AMD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Progression to visual loss (loss of 3 or more lines on logMAR chart) · people with AMD
Vitamin E showed no clear difference in progression to visual loss (loss of 3 or more lines on logMAR chart) compared with placebo (low certainty).
1 finding from 1 review
Quality of life · people with AMD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse effects · people with AMD
It is very uncertain whether vitamin E changes adverse effects compared with placebo (very low certainty).
1 finding from 1 review
no estimate extracted
4 participants
Very low
Resource use and costs · people with AMD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Any AMD · general population
Vitamin E showed no clear difference in any AMD compared with placebo (high certainty).
1 finding from 1 review
Progression to late AMD (neovascular AMD, geographic atrophy or both) · general population
Vitamin E showed no clear difference in late AMD (either neovascular AMD or geographic atrophy or both) compared with placebo (moderate certainty).
1 finding from 1 review
Neovascular AMD · general population
It is very uncertain whether vitamin E changes neovascular AMD compared with placebo (very low certainty).
1 finding from 1 review
Geographic atrophy · general population
It is very uncertain whether vitamin E changes geographic atrophy compared with placebo (very low certainty).
1 finding from 1 review
Quality of life · general population
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse effects (AE) · general population
1 finding from 1 review
no estimate extracted
Studies not reported
Low