Findings

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5 questions · 5 findings · 1 reviews · Oral Health

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No studies found 0 · 0%GRADE not reported 5 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Vitamin B12 (sublingual, 1000 mcg daily for 6 months) vs placebo

Average duration of RAS episode (days) · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Vitamin B12 (sublingual, 1000 mcg daily for 6 months) led to lower average duration of RAS episode (days) compared with placebo; GRADE not reported.

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
6 months
MD -2.86 [-5.39, -0.33]
1 study · 58 participants
GRADE not reported

Vitamin B12 (sublingual, 1000 mcg daily for 6 months) vs placebo

Pain score · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Vitamin B12 (sublingual, 1000 mcg daily for 6 months) led to lower pain score compared with placebo; GRADE not reported.

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
6 months
MD -1.72 [-2.70, -0.74]
1 study · 58 participants
GRADE not reported

Vitamin B12 (sublingual, 1000 mcg daily for 6 months) vs placebo

Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
6 months
No adverse events were associated with receiving vitamin B12 or placebo in this study.
1 study · 58 participants
GRADE not reported

Vitamin B12 (sublingual, 1000 mcg daily for 6 months) vs placebo

'No ulcer' status during last 2 months of treatment · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Vitamin B12 (sublingual, 1000 mcg daily for 6 months) led to higher 'No ulcer' status during last 2 months of treatment compared with placebo; GRADE not reported.

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
6 months
RR 3.27 [1.23, 8.66]
1 study · 58 participants
GRADE not reported

Vitamin B12 (sublingual, 1000 mcg daily for 6 months) vs placebo

Frequency of outbreaks per month · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Vitamin B12 (sublingual, 1000 mcg daily for 6 months) led to lower frequency of outbreaks per month compared with placebo; GRADE not reported.

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
6 months
MD -8.74 [-16.62, -0.86]
1 study · 58 participants
GRADE not reported