Findings

What do systematic reviews say?

8 questions · 9 findings · 1 reviews · Headline outcomes only

No studies found 0 · 0%GRADE not reported 1 · 11.1%Very low 0 · 0%Low 1 · 11.1%Moderate 7 · 77.8%High 0 · 0%

Incidence of typhoid fever – year 1 · adults and children of 2 years of age and older

Vi‐rEPA vaccine (2 doses) probably leads to lower incidence of typhoid fever – year 1 compared with control (moderate certainty).

1 finding from 1 review

Vaccines for preventing typhoid fever 2018 · Cochrane Headline outcomes only
RR 0.06 [0.01, 0.25]
1 study · 12008 participants
Moderate

Incidence of typhoid fever – year 2 · adults and children of 2 years of age and older

Vi‐rEPA vaccine (2 doses) probably leads to lower incidence of typhoid fever – year 2 compared with control (moderate certainty).

1 finding from 1 review

Vaccines for preventing typhoid fever 2018 · Cochrane Headline outcomes only
RR 0.13 [0.04, 0.44]
1 study · 12008 participants
Moderate

Cumulative cases of typhoid fever at 2 years · adults and children of 2 years of age and older

Vi‐rEPA vaccine (2 doses) probably leads to lower cumulative cases of typhoid fever at 2 years compared with control (moderate certainty).

2 findings from 1 review

Vaccines for preventing typhoid fever 2018 · Cochrane Headline outcomes only
RR 0.09 [0.04, 0.22]
1 study · 12008 participants
Moderate
Vaccines for preventing typhoid fever 2018 · Cochrane Headline outcomes only
RR 0.11 [0.05, 0.23]
1 study · 12008 participants
Moderate

Serious adverse events · adults and children of 2 years of age and older

1 finding from 1 review

Vaccines for preventing typhoid fever 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12008 participants
GRADE not reported

Fever · adults and children of 2 years of age and older

Vi‐rEPA vaccine (2 doses) probably leads to higher fever after Vi‐rEPA (dose1) compared with control (moderate certainty).

1 finding from 1 review

Vaccines for preventing typhoid fever 2018 · Cochrane Headline outcomes only
RR 2.54 [1.69, 3.62]
1 study · 12008 participants
Moderate

Fever after Vi‐rEPA (dose2) · adults and children of 2 years of age and older

Vi‐rEPA vaccine (2 doses) probably leads to higher fever after Vi‐rEPA (dose2) compared with control (moderate certainty).

1 finding from 1 review

Vaccines for preventing typhoid fever 2018 · Cochrane Headline outcomes only
RR 4.39 [2.85, 6.77]
1 study · 11091 participants
Moderate

Erythema · adults and children of 2 years of age and older

Vi‐rEPA vaccine (2 doses) showed no clear difference in erythema after Vi‐rEPA (dose 2) compared with control (low certainty).

1 finding from 1 review

Vaccines for preventing typhoid fever 2018 · Cochrane Headline outcomes only
RR 2.01 [0.19, 22.21]
1 study · 11091 participants
Low

Swelling at injection site after Vi‐rEPA (dose 2) · adults and children of 2 years of age and older

Vi‐rEPA vaccine (2 doses) probably leads to higher swelling at injection site after Vi‐rEPA (dose 2) compared with control (moderate certainty).

1 finding from 1 review

Vaccines for preventing typhoid fever 2018 · Cochrane Headline outcomes only
RR 20.15 [2.71, 150.08]
1 study · 11091 participants
Moderate