What do systematic reviews say?

Very low protein diet vs low or normal protein diet

Very low protein diet showed no clear difference in death (all causes) compared with low or normal protein diet (moderate certainty).

• Low protein diets for non‐diabetic adults with chronic kidney disease 2020 · Cochrane Headline outcomes only
  RR 1.26 [0.62, 2.54]
  6 studies · 681 participants
  Moderate

Very low protein diet vs low or normal protein diet

Very low protein diet probably leads to lower ESKD compared with low or normal protein diet (moderate certainty).

• Low protein diets for non‐diabetic adults with chronic kidney disease 2020 · Cochrane Headline outcomes only
  RR 0.64 [0.49, 0.85]
  10 studies · 1010 participants
  Moderate

Very low protein diet vs low or normal protein diet

• Low protein diets for non‐diabetic adults with chronic kidney disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 456 participants
  Low